How to pronounce it: Psoriatic - So-ri-at-ic Arthritis - ar-thry-tus
Psoriatic arthritis (PsA) is a chronic inflammatory disease. It affects the joints and often causes enthesitis (inflammation where tendons and ligaments attach to bones). PsA can also impact the skin and eyes. While most people with PsA have a psoriasis rash, it can be hidden (like on the scalp) or may not show up for years.
Flares: Periods of worsening symptoms are called flares. A flare can last for hours, days, weeks, or months.
Physical Activity: Condition improves with activity and exercise and worsens with rest.
Comorbidities: When inflammation is left uncontrolled due to lack of proper treatment, comorbidities can develop. 70% of patients with chronic, lifelong disease will develop comorbidities, including dual or triple diagnoses.
Family History:
Autoimmune diseases often run in families, indicating a potential genetic predisposition where that gene can cause disease. Autoinflammatory diseases can occur multiple times in a family, but is based off of genetic mutation. It is not a gene that causes the disease— but a mutation on the gene that can cause the disease which can then be passed on to the next generation.
Fatigue: Severe fatigue or exhaustion that may not be helped by caffeine/stimulants and can happen even after a long period of rest.
Cognitive Dysfunction: Brain fog or periods of time where thinking gets clouded and it becomes difficult to concentrate.
Flu-like symptoms: Without having the flu- nausea, muscle weakness, and general malaise.
Fever: Typically low grade in autoimmune (with exception of juvenile idiopathic arthritis) and higher grade in autoinflammatory (% strongly varies per disease).
Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.
Stiffness: Severe stiffness in one or more joints, especially in the morning or after sitting for long periods of time.
Joint Pain: Episodes of joint pain that may last for hours, days, or even weeks, that can appear and disappear suddenly. Often described as “jumping pain” into different locations.
Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare"). Some people will experience all of the above symptoms, others only a few.
If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a specialist.
There’s no single test for PsA. Rheumatologists will use a combination of physical exams, blood tests, imaging (like x-rays), and family history. During the exam, they will:
Blood tests will check for C-reactive protein (CRP) and rheumatoid factor (RF). Most people with PsA do not have a positive RF. If RF is positive, doctors may consider a diagnosis of Rheumatoid Arthritis (RA) instead.
Imaging tests, such as x-rays, often focus on the hands and feet to look for damage. PsA can cause unique joint damage not seen in other types of AiArthritis diseases. However, x-rays may not show early signs, so MRIs or other imaging might be needed.
Doctors will also check if symptoms have lasted more than 6 weeks and look for patterns that differentiate PsA from other types of arthritis.
Blood tests can show inflammation (ESR and CRP) or a positive Rheumatoid Factor (RF+), but these are not required for a diagnosis. Many people with RA do not have these markers in their blood.
To help with diagnosis, doctors may use a points system from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR). This system assigns points based on your test results and symptoms to determine if you have psoriatic arthritis.
Treatments are tailored to each individual's disease, but visit our Treatment Options page to learn more about the different types of treatments that are used for Psoriatic Arthritis.
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